The best thing to do next is a simple urine pregnancy test at home. If the test is negative, you may wait for another week to see if menstruation starts naturally. If it is still delayed, please repeat the pregnancy test. You may need to see a gynaecologist for a pelvic scan if the period is delayed for more than 2-3 weeks; the appropriate medicine should be given to induce menstrual flow after the scan. If it is indeed an unplanned pregnancy, you may then arrange with the gynaecologist for the appropriate management.

Dear bluecotton, 
It sounds like your mum has recurrent episodes of angioedema which could be an allergic reaction to various triggers (e.g. food, medications, insect bites or stings) especially if associated with an itchy rash like hives. One particular type of medication that can cause this is an ACE inhibitor (e.g. lisinopril,  enalapril) which is a drug used for high blood pressure and also heart conditions. It is important to make sure the episodes of lip swelling are not associated with difficulty breathing or wheezing that may suggest a serious reaction that needs immediate medical attention. It doesn't seem like the leg cramp is related though. You can consult your family physician or an allergist. 
Take care

Dear bluecotton, 
It sounds like your mum has recurrent episodes of angioedema which could be an allergic reaction to various triggers (e.g. food, medications, insect bites or stings) especially if associated with an itchy rash like hives. One particular type of medication that can cause this is an ACE inhibitor (e.g. lisinopril,  enalapril) which is a drug used for high blood pressure and also heart conditions. It is important to make sure the episodes of lip swelling are not associated with difficulty breathing or wheezing that may suggest a serious reaction that needs immediate medical attention. It doesn't seem like the leg cramp is related though. You can consult your family physician or an allergist. 
Take care

Vaccinations during pregnancy should only be considered when the need for it exceeds the risk to the pregnancy. The usual vaccines that are recommended for all pregnancies (unless special circumstances dictates otherwise) include vaccines against Influenza and Pertussis (Whooping Cough). In addition, as we battle the COVID pandemic, the COVID vaccine is also recommended for pregnant women, albeit with limited long-term safety data.

Currently there is no evidence to suggest that vaccines (COVID or others) can impair fertility, although certain live vaccines should be avoided during pregnancy or you should avoid conceiving within 4-6 weeks of exposure to certain live vaccines (e.g. MMR).

Factors contributing to infertility may lie in either or both partners; the most common conditions encountered in infertile couples include advanced age, low egg count, low sperm count, failure to ovulate and endometriosis. Hence, it is likely that there are more medical factors in the female that can result in infertility, although not exclusively. "Enhancement" of fertility has to be individualised accordingly to the profile of each couple, depending on the unique fertility problems they face.

A thorough interview of both partners, a detailed pelvic assessment of the female and a basic semen analysis will enable a fertility specialist to establish the diagnosis of the causes for infertility in most cases. Sometimes, additional blood tests or scans may be required to aid in the diagnostic process, for the more challenging cases. In Singapore, the reference ranges used for semen analysis are that of WHO.

The Combine Oral Contraceptive (COC) pills are  supposed to be effective in preventing pregnancy when used properly and fertility should return quickly after cessation of use. However, we do see some women experiencing a delay in return of fertility after using COCs. It is likely that the COCs might have been masking the symptoms of underlying conditions that impair fertility, rather than the COCs causing the impairment of fertility directly. Conditions such as endometriosis and PCOS are easily concealed by COCs as menstrual cycles tend to be regular and less painful, therefore the unsuspecting women do not notice their presence, until they stop using COCs. 

Yes, the age of a woman will have significant impact on her fertility. This starts to be more evident after the age of 37-38 years, in general.

As the age of our first-time mothers increase, we see an increase in prevalence of infertility in our population. Biologically speaking, the reproductive window of a female is a lot smaller than that of a male, often dipping into the worrying (sub-fertile) range after the age of 37-38 years old in general. Of course, this can vary very widely between different women. There are many reasons for infertility itself and hence the treatment, each targeting different conditions, will be varied. It is important to accurately diagnose the medical conditions present and tackle each one accordingly. For that, you will need the help of a fertility specialist.